• Adaptive downregulation of mitochondrial function in down syndrome. Helguera P, Seiglie J, Rodriguez J, Hanna M, Helguera G, Busciglio J. Cell Metab. 2013 Jan 8;17(1):132-40. doi: 10.1016/j.cmet.2012.12.005.
  • A role for thrombospondin-1 deficits in astrocyte-mediated spine and synaptic pathology in Down’s syndrome. Garcia O, Torres M, Helguera P, Coskun P, Busciglio J. PLoS One. 2010 Dec 2;5(12):e14200. doi: 10.1371/journal.pone.0014200.
  • ets-2 promotes the activation of a mitochondrial death pathway in Down’s syndrome neurons. Helguera P, Pelsman A, Pigino G, Wolvetang E, Head E, Busciglio J. J Neurosci. 2005 Mar 2;25(9):2295-303.
  • NAP and ADNF-9 protect normal and Down’s syndrome cortical neurons from oxidative damage and apoptosis. Busciglio J, Pelsman A, Helguera P, Ashur-Fabian O, Pinhasov A, Brenneman DE, Gozes I. Curr Pharm Des. 2007;13(11):1091-8.
  • Cryopreservation of cortical tissue blocks for the generation of highly enriched neuronal cultures.
  • Rahman AS, Parvinjah S, Hanna MA, Helguera PR, Busciglio J. J Vis Exp. 2010 Nov 11;(45). pii: 2384. doi: 10.3791/2384.
  • Phosphorylation of actin-depolymerizing factor/cofilin by LIM-kinase mediates amyloid beta-induced degeneration: a potential mechanism of neuronal dystrophy in Alzheimer’s disease. Heredia L, Helguera P, de Olmos S, Kedikian G, Solá Vigo F, LaFerla F, Staufenbiel M, de Olmos J, Busciglio J, Cáceres A, Lorenzo A. J Neurosci. 2006 Jun 14;26(24):6533-42.